Junichi Tokuda, PhD

Junichi Tokuda, PhD

Associate Professor of Radiology, Harvard Medical School
Junichi Tokuda, PhD

The main focus of my research has been the development and clinical application of new imaging, software, and robot technologies for image-guided interventions, particularly magnetic resonance imaging (MRI)-guided percutaneous interventions. In the early stage in my career, I developed 4-dimensional MR imaging to compensate for respiratory motion of the liver during MR-guided microwave liver ablation. More recently, I have been working on novel imaging techniques for guiding and monitoring MR-guided interventions, including 1) frozen-tissue imaging based on ultrashort echo-time (UTE) MRI to delineate the area under the critical temperature (- 20-40 °C) on MRI for cryoablation of kidney, prostate, and liver, 2) intraprocedural quantitative T1 and T2 mapping for MRI-guided biopsy using MR Fingerprinting in collaboration with Dr. Vikas Gulani’s group at Case Western Reserve University to test MR Fingerprinting technology during MRI-guided prostate biopsy, and 3) assessment of tumor hypoxia using conventional R2* mapping and a novel silicone-based oxygen sensor during MR-guided gynecological brachytherapy in collaboration with Dr. Michael Cima’s group at MIT Koch Institute and Dr. Larissa Lee at BWH Radiation Oncology.

I am also interested in developing and clinically testing new devices to assist MR-guided interventions. I developed guidance software and robotic devices that enables transperineal targeted prostate biopsy under direct MRI-guidance. The software has been used in more than 400 clinical cases, which resulted in several publications in high impact journals. A needle guide device, Smart Template, was used in 43 clinical cases and became one of the earliest clinical studies on MRI-guided robotic prostate biopsy. More recently, a 4-DOF needle guide manipulator co-developed with Worcester Polytechnic Institute and Johns Hopkins University has been tested in 30 patients. Recently, I worked with physicists and radiation oncologists to clinically test MR tracking for guiding high-dose-rate brachytherapy catheter for MR-guided gynecological brachytherapy.

Contact Information

Department of Radiology
Brigham and Women's Hospital
329 Thorn Research Building
75 Francis St.
Boston, MA 02115

Research Role